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KMID : 0043320180410121162
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Archives of Pharmacal Research
2018 Volume.41 No. 12 p.1162 ~ p.1169
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New triterpenoids from Staphylea bumalda flower buds and their neuroprotective activity against H2O2-induced injury in vitro
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Zhang Zheng-Xi
Feng Kun
Sui Xian-Jin
Wang Wen-Shu
Wang Lin
Wang Dong-Hong
Luo Xiao-Min
Chen Xiao-Fei
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Abstract
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Four new acylated triterpene glycosides with aliphatic chains (4?7) as well as five known triterpenoids were isolated from the flower buds of Staphylea bumalda with bioassay guidance. Their structures were determined on the basis of spectral techniques, including IR, 1D and 2D NMR, and HR-APCI-MS. Most compounds (except 8) were isolated from S. bumalda for the first time. Additionally, the neuroprotective effects of 1 and 4?9 on suckling rat primary cultured hippocampal neurons against H2O2-induced injury were evaluated in vitro. The four new triterpenoids (4?7) showed neuroprotective effects, which increased the cell viability to over 74% at different concentrations, which was higher than the negative control (59%), while compounds 1 and 8?9 exhibited cytotoxic activity.
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KEYWORD
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Staphylea bumalda, Staphyleaceae, Acylated triterpene glycosides, Neuroprotective activity
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